The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors.While clonal selection in response to particular antigens has g35 coupe fender been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire.Here, using mathematical modeling and statistical analyses of T cell receptor sequencing data, we develop a quantitative theory of human T cell dynamics compatible with the statistical laws of repertoire organization.
We find that clonal expansions during a perinatal time window leave a long-lasting imprint stickers logos dallas cowboys on the human T cell repertoire, which is only slowly reshaped by fluctuating clonal selection during adult life.Our work provides a mechanism for how early clonal dynamics imprint the hierarchy of T cell clone sizes with implications for pathogen defense and autoimmunity.